Single-Day Protein LC-MS Bioanalysis
July 11, 2024
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This paper explains how next-generation trypsins offer faster protein digestion for LC-MS analysis with comparable performance to standard methods.
In Vitro Models for Predicting Transporter-Mediated DDIs
July 11, 2024
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This paper discusses how in vitro studies can be used to predict drug-drug interactions (DDIs) caused by transporters in the body.
Development and Validation of Immunogenicity Assays for ADCs
July 11, 2024
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CASE STUDY – Addressing ADC Regulatory Challenges by Providing Validated Assays for Multi-Domain Proteins…
Development and Validation of an Immunogenicity Assay for Detection of Anti-AAV Antibodies
July 11, 2024
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CASE STUDY – ANTI-AAV ANTIBODIES. We are experienced with a wide range of different proteins and therapeutics…
Pharmacokinetics (PK) Urine Analysis
July 10, 2024
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Whereas blood is collected for analysis at a discrete time point, urine is collected over periods of time known as collection intervals…
Challenges of Developing an ADA Assay for Bispecific Antibody Therapeutics and ADA Characterization
July 10, 2024
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Bispecifics (Bs) are biopharmaceutical products that bind to two different targets (epitopes). These are mainly two types: IgG-like (antibodies Abs) and non-IgG-like which include Bites (bispecific T-cell engager) and DARTs (Dual-affinity Re-targeting Antibody)…