Our Research
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In Vitro Models for Predicting Transporter-Mediated DDIs
This paper discusses how in vitro studies can be used to predict drug-drug interactions (DDIs) caused by transporters in the body.
Development and Validation of Immunogenicity Assays for ADCs
CASE STUDY – Addressing ADC Regulatory Challenges by Providing Validated Assays for Multi-Domain Proteins…
Development and Validation of an Immunogenicity Assay for Detection of Anti-AAV Antibodies
CASE STUDY – ANTI-AAV ANTIBODIES. We are experienced with a wide range of different proteins and therapeutics…
Pharmacokinetics (PK) Urine Analysis
Whereas blood is collected for analysis at a discrete time point, urine is collected over periods of time known as collection intervals…
Challenges of Developing an ADA Assay for Bispecific Antibody Therapeutics and ADA Characterization
Bispecifics (Bs) are biopharmaceutical products that bind to two different targets (epitopes). These are mainly two types: IgG-like (antibodies Abs) and non-IgG-like which include Bites (bispecific T-cell engager) and DARTs (Dual-affinity Re-targeting Antibody)…
What Makes a Good LC-MS/MS Bioassay?
Liquid chromatography linked to tandem mass spectrometry (LC–MS/MS, LC-MS) is the “go-to” method for pharmacokinetics and metabolism studies across drug development with recent advances in separation, throughput and methods for analyzing protein biotherapeutics…