Protein and Oligonucleotide LC-MS

Offering specialized Protein and Oligonucleotide LC-MS services.

Oligonucleotides, aptamer-drug-conjugates (ApDCs), antibody-oligonucleotide conjugates (AOCs) and mRNA drugs/vaccines are polyanionic large molecules. Their bioanalysis is extremely challenging from sample preparation to instrument analysis. Some of Resolian’s core team members have worked on the regulated bioanalysis of oligonucleotides since 2006.

Resolian has established six most commonly used bioanalytical technology platforms (see below) to support the ADME and PK/PD studies of oligonucleotide therapeutics/conjugates in different research and development stages, from early in vitro drug screening to IND/NDA filing studies.

Additionally, Resolian has developed three different assay platforms (two step assay, sandwich assay and bridging assay) to evaluate the ADA of oligonucleotide therapeutics.

Reach out to us directly to learn more about Resolian’s Protein and Oligonucleotide LC-MS services.

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Our Bioanalytical Technology Platforms

  • LC-HRAM
  • LC-MS/MS
  • Hybridization based LC-fluorescence
  • Hybridization ELISA
  • Hybridization MSD
  • RT-Qpcr
  • FLD

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Zhiyang Zhao, Ph.D.

Chief Scientific Officer

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Zhiyang Zhao, Ph.D., serves as Chief Scientific Officer (CSO) at Resolian. Dr. Zhao has over 30 years of pharmaceutical industry experience with special focus on drug metabolism and bioanalysis of small and large molecules in drug discovery and development. Dr. Zhao has previously held positions at Pfizer, GlaxoSmithKline, and Amgen. Before joining Resolian in 2015, Dr. Zhao served as Site Director of Preclinical Research at Amgen in Cambridge, Massachusetts, for over a decade. 

Currently, Dr. Zhao serves as an Adjunct Professor at the Eshelman School of Pharmacy of the University of North Carolina at Chapel Hill, North Carolina, and as Editor-in-Chief of Drug Metabolism & Bioanalysis Letters, a journal by Bentham Science, which publishes in all areas of drug metabolism and bioanalysis. Dr. Zhao received his Ph.D. degree in Medicinal Chemistry from Virginia Polytechnic and State University (popularly known as Virginia Tech) in Blacksburg, Virginia. 

Patrick Bennett

Chief Executive Officer

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Patrick Bennett has over 35 years of experience in pharmaceutical analysis and laboratory management. Now Chief Business Officer at Resolian, Patrick’s experience includes the roles of Strategic Marketing Director for Pharma with Thermo Fisher Scientific, LabCorp, and Vice President of Strategy and Development with PPD. 

Patrick earned a B.S. degree in Toxicology and a M.S. degree in Pharmacology from the College of Pharmacy and Allied Health at St. John’s University and an M.B.A in International Marketing from the Martin J. Whitman School of Management at Syracuse University.