Peptide Analysis

High sensitivity methods are often required for peptide bioanalysis owing to their enhanced efficacy. Resolian’s team has developed and validated methods using LC-MS/MS to quantify levels of peptides in plasma at levels as low as 10 pg/mL.

Often the amino acid composition within peptides or their specific conjugation to other modalities can lead to undesirable binding with labware during extraction or LC-MS/MS measurement. Resolian’s team is experienced in rapidly predicting/diagnosing these issues and implementing solutions to deliver robust methodologies.

Peptides can often be susceptible to degradation, due to the presence of a wide range of endogenous peptidases. Resolian possesses experience in assessing their stability and can advise you on pre-analytical stabilization techniques to control this.

Building upon this, Resolian can implement capabilities in High Resolution MS to identify these degradation products (metabolites) and develop methods to quantify them.

Beyond their experience with peptide bioanalysis, Resolian’s dedicated LC-MS team offers you integrated support from early discovery to late-phase clinical trials, advising you on the regulations applicable to your project.