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Large Molecule LC-MS/MS

Global capabilities for large molecule LC-MS/MS assays.

To best align with targeted assays for your biologic or large molecule therapeutics, developed assays can quantify intact large molecules and their metabolites directly or through signature peptide(s) using LC-HRAM or LC-MS/MS methods.

These are robustly established with high sensitivity by implementing proven extraction and purification techniques, coupled with options of bottom-up proteolytic digestion or top-down intact analysis.

These molecules include

Antibodies/ADC
Native/recombinant proteins
Peptides/PDC

Reach out to us directly to learn more about Resolian’s Large Molecule LC-MS/MS services.

Featured Techniques and Strategies

Reagent free assays: Faster project progression and a translatable assay format through drug development
Mass-based detection: Overcome challenges associated with non-specific immunoassay reagents (immunoassay can be hybridized to LC-MS for greater sensitivity)
Ability to resolve closely related species: Provide structural information on the fate/stability of the protein
Complementary to immunoassay: Can offer a simpler route to a “total” assay
Possibility to multiplex analytes: Multiple proteins or multiple surrogate peptides from a single protein can be monitored through a single measurement