Large Molecule LC-MS/MS
Global capabilities for large molecule LC-MS/MS assays.
To best align with targeted assays for your biologic or large molecule therapeutics, developed assays can quantify intact large molecules and their metabolites directly or through signature peptide(s) using LC-HRAM or LC-MS/MS methods.
These are robustly established with high sensitivity by implementing proven extraction and purification techniques, coupled with options of bottom-up proteolytic digestion or top-down intact analysis.
These molecules include
- Antibodies/ADC
- Native/recombinant proteins
- Peptides/PDC
Reach out to us directly to learn more about Resolian’s Large Molecule LC-MS/MS services.
Featured Techniques and Strategies
- Reagent free assays: Faster project progression and a translatable assay format through drug development
- Mass-based detection: Overcome challenges associated with non-specific immunoassay reagents (immunoassay can be hybridized to LC-MS for greater sensitivity)
- Ability to resolve closely related species: Provide structural information on the fate/stability of the protein
- Complementary to immunoassay: Can offer a simpler route to a “total” assay
- Possibility to multiplex analytes: Multiple proteins or multiple surrogate peptides from a single protein can be monitored through a single measurement
Our Bioanalytics Resources
Our Labs – Large Molecule LC-MS/MS
America
Kingdom
Choose a location
United Kingdom
Bioanalytics Fordham
Your experts in:
- LC-MS
- Immunoassay
- Biomarkers
- Protein and oligonucleotide LC-MS
- Immunogenicity
- Flow cytometry
+ Over 25 years of experience in Europe
Learn MoreAnalytical Sciences Fordham and Sandwich
Your specialist in:
- GMP and CMC testing
- Materials Science
+ Over 20 years of experience in Europe
See Fordham LabSee Sandwich Lab
North America
Bioanalytics Malvern
Your experts in:
- MetID, animal dosing (nonGLP, rodent)
- LC-MS
- Immunoassay
- Protein and oligonucleotide LC-MS
- Immunogenicity
- Biomarkers
- DMPK
- PCR
+ Over 15 years of experience in the US
Learn MoreAustralia
Bioanalytics Brisbane
Your experts in:
- LC-MS
- Immunoassay
- Biomarkers
- Early phase clinical research/phase I studies
Specialists in Australia
Learn MoreChina
Bioanalytics Chongqing
Your experts in:
- LC-MS
- Immunoassay
- Biomarkers
- Protein and oligonucleotide LC-MS
- Antibody Drug Conjugates
- mRNA assays
+ Over 20 years of industry experience
Learn More
