In Vivo Testing Services
Accredited and assured facility offering in vivo research.
In Vivo Pharmacokinetics
Resolian provides an AAALAC-accredited, and NIH OLAW-assured facility that offers non-GLP pre-clinical testing in vivo research.
Resolian is committed to supporting in vivo research, with a particular focus on research involving mice and rats, and performs all in vivo tasks associated with determining the pharmacokinetic profile and bioavailability of all advancing Drug Discovery compounds.
We are dedicated to continuous improvement, maintaining flexibility, innovating unique solutions, developing strong internal and external connections, and adhering to sustainable practices.
The members of the IACUC work closely with investigators to ensure that all studies are carried out appropriately and in accordance with all pertinent regulations.
Reach out to us directly to learn more about Resolian’s In Vivo Testing Services.
In Vivo DDI Study Experience
Study capabilities include:
- Tissue distribution
- Formulation tolerability
- Dose escalation
- IV/PO screening
- Cassette PK screenings of up to 5 compounds simultaneously
- Vehicle comparison selection
- Repeat administration for tolerability
- Dermal
- Behavioral observation studies
- Intravenous infusion
- Microsampling
Proficient in multiple routes of administration both in rats and mice:
- Intravenous
- Oral
- Intraperitoneal
- Subcutaneous
- Intramuscular
- Femoral vein
- Portal vein
- Jugular vein
- Intra-nasal
Biological sample collection methods:
- Serial tail vein bleeding
- Pre-catheterized animals from pre-approved animal vendor
- Retro-orbital collection
- Cardiac puncture
- Abdominal aorta sampling
- Bile duct cannulation (bile, feces, and urine collection)
- Skeletal/cardiac muscle, bone, and organ identification and dissection
- Bone marrow extraction
- Lymph node collection
- CSF collection rats and mice one collection all terminal
Small animal surgical techniques:
- Administration of anesthesia to experimental rats and mice
- Venous (jugular, portal, femoral) cannulation
- Pyloric ligation for stomach bypass, gastric and intraduodenal injection
- Intra-nasal dosing
