Drug Metabolism and Pharmacokinetics
Supporting early drug discovery and late-stage drug development with state-of-the-art technologies.
With decades of experience in absorption, distribution, metabolism, and excretion (ADME) studies, the Resolian ADME team offers you expertise in the following in vitro studies:
- Metabolic stability in various matrices: e.g., plated hepatocytes and relay
- Metabolite identification and profiling
- Blood partitioning
- Protein binding using equilibrium dialysis, ultracentrifugation and ultrafiltration
- Reaction phenotyping (CYP and UGT)
- Cell permeability
- Hepatic uptake assays
- Drug-Drug Interaction Studies
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- CYP induction
- CYP inhibition (direct and time-dependent)
- UGT inhibition
- MAO inhibition
- Drug transporter substrate and inhibition assays (uptake and efflux transporter studies using transfected cells and vesicles)
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Reach out to us directly to learn more about Resolian’s Drug Metabolism and Pharmacokinetics services.
