Immunogenicity

Developing, validating and implementing anti-drug antibody (ADA) immunogenicity and neutralizing antibody (nAb) assays.

Services:

  • Assay development, validation and sample analysis
  • Pre-clinical and clinical immunogenicity and nAb assays
  • Ligand binding and cell-based assays
  • Acid dissociation
  • ACE
  • SPEAD
  • Isotyping assays

Therapeutic Modalities:

  • Monoclonal antibodies (mAbs)
  • Antibody fragments (Fab, nanobody, domain Abs)
  • Antibody drug conjugates (ADCs)
  • Proteins
  • Peptides
  • Bispecifics
  • Biosimilars
  • AAVs, gene therapy

Technologies:

  • ELISA (absorbance, luminescence, fluorescence)
  • GyroLab xPand, xPlore™
  • Quanterix (HDX Simoa)
  • Electrochemiluminescence (MSD Sector Imager 6000, QuickPlex)
  • Luminex (Magpix, Flexmap 3D)
  • Flow cytometry (Beckman Coulter CytoFLEX)
  • qPCR (QuantStudio™ 7) and Hybridization ELISA
  • Luminex Flexmap 3D
  • Protein Simple Ella
  • Thermo Scientific NanoDrop
  • Hamilton STAR Robotics

Reach out to us directly to learn more about Resolian’s Immunogenicity services.

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Zhiyang Zhao, Ph.D.

Chief Scientific Officer

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Zhiyang Zhao, Ph.D., serves as Chief Scientific Officer (CSO) at Resolian. Dr. Zhao has over 30 years of pharmaceutical industry experience with special focus on drug metabolism and bioanalysis of small and large molecules in drug discovery and development. Dr. Zhao has previously held positions at Pfizer, GlaxoSmithKline, and Amgen. Before joining Resolian in 2015, Dr. Zhao served as Site Director of Preclinical Research at Amgen in Cambridge, Massachusetts, for over a decade. 

Currently, Dr. Zhao serves as an Adjunct Professor at the Eshelman School of Pharmacy of the University of North Carolina at Chapel Hill, North Carolina, and as Editor-in-Chief of Drug Metabolism & Bioanalysis Letters, a journal by Bentham Science, which publishes in all areas of drug metabolism and bioanalysis. Dr. Zhao received his Ph.D. degree in Medicinal Chemistry from Virginia Polytechnic and State University (popularly known as Virginia Tech) in Blacksburg, Virginia. 

Patrick Bennett

Chief Executive Officer

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Patrick Bennett has over 35 years of experience in pharmaceutical analysis and laboratory management. Now Chief Business Officer at Resolian, Patrick’s experience includes the roles of Strategic Marketing Director for Pharma with Thermo Fisher Scientific, LabCorp, and Vice President of Strategy and Development with PPD. 

Patrick earned a B.S. degree in Toxicology and a M.S. degree in Pharmacology from the College of Pharmacy and Allied Health at St. John’s University and an M.B.A in International Marketing from the Martin J. Whitman School of Management at Syracuse University.